Faculty members

Dr. Anil Dev Pant, Associate Professor, Head of Department Dr. Ram Chandra Adhikari, Professor Dr. Abhimanyu Jha, Professor Dr. Anjan Shrestha, Associate Professor Dr. Shovana Karki Thapa, Associate Professor Dr. Usha Manandhar, Lecturer Dr. Shreya Shrivastav, Lecturer Dr Nisha Sharma, Lecturer Dr. Shankar Kafle, Lecturer Dr. Bibek KC, Lecturer Dr. Alina Karna, Registrar

Introduction:

Department of Pathology was established along with the MBBS course in Maharajgunj Medical Campus in 1984 and the former Dean of IOM, Prof. Hari Govind Shrestha was the pioneer in establishing the department. Also, with his initiation, the first post graduate program in Pathology in Nepal was established in MMC. He was the first HOD in the department.

Department of Pathology undertakes teaching learning activities to medical undergraduates, 17 postgraduates, and 3 fellows in form of Lectures, Structured Interactive Sessions, Laboratory Exercise, Journal Club, Subject and Gross Seminars, Slide Seminars and Interdepartmental Conferences. Routine reporting of Histopathology, Cytopathology and Hematology are performed by consultants on a daily basis. These all form an excellent opportunity to teaching learning activities.   In addition, B.M.L.T., B Pharm, BSc MIT and Nursing (BSc, BN, BMidW) are some of the academic programs the department is currently involved in.  Regular research work and publications are also an important part of the departmental activity.

Hospital services have been provided in form of Histopathology, Cytopathology (FNAC/USG Guided FNAC/CT guided FNAC/PAP Smears/Fluids/Sputum/BAL), Hematology (all lab services including bone marrow examination), Capillary Electrophoresis (Hemoglobin, Protein, and Immunotyping), Factor Assays, Blood Banking with Component Separation, Imprint Cytology, Frozen section, Special staining and chemistry, and Immunohistochemistry. Recently, Liquid Based Cytology and Flow Cytometry have been started.  In the near future, the department is planning to start ANA-IFA, FISH and Immunofluorescence Microscopy as well.  We hope to further improve Blood Bank Services and have recently hired a specialist MD in Transfusion Medicine.

We also have competent technical staffs consisting of technologists, technicians and assistants.  There are 13 staff in hematology, 11 in histopathology, and 12 in Blood Bank.

List of major services provided in the department (2080 Baisakh to 2080 Chaitra)

1. Histopathology (biopsy, immunohistochemistry): 9415
2. Cytopathology (Fluids, pap smear and FNAC): 5789
3. Hematopathology:

Bone marrow and aspirations: 712

Electrophoresis :1239

CBC with PBS: 11220

CBC, ESR and others: 90,000.

Future Plan: HLA Typing Flowcytometry FISH Cytogenetics Immunoflorescence

PAPER PRESENTATIONS/PUBLICATIONS IN LAST FIVE YEARS.

• Adhikari, Ram & Sayami, Gita & Lee, Min & Basnet, Ranga & Shrestha, Pradeep & Shrestha, Hari. (2003). Kikuchi-Fujimoto Disease in Nepal: A Study of 6 Cases. Archives of Pathology & Laboratory Medicine. 127. 1345-1348. 10.5858/2003-127-1345-KDINAS.

• Adhikari, Ram & Pokharel, B & Shrestha, Hasan. (2003). GASTRIC ADENOCARCINOMA AND HELICOBACTER PYLORI INFECTION. Journal of Nepal Medical Association. 41. 457-462. 10.31729/jnma.681.

• Ghimire, Prinska & Magar, Sagar & Khanal, Surendra & Basnet, Alina & Thapaliya, Sahil & Panthi, Bishal & Karki, Shovana & Acharya, Sulav & Bali, Kanchana & Adhikari, Aayush. (2023). Histological and immunohistochemical diagnosis of Secretory Carcinoma of Parotid in a low-resource setting: A case report. 10.22541/au.168795367.76514701/v1.

• Karki, Shovana. (2022). Histopathological Findings of Pancreaticoduodenectomy Specimens in a Tertiary Care Hospital in Nepal.

• Panthee, Nirmal & Pradhan, Sidhartha & Koirala, Raamesh & Pant, Anil & Pokhrel, Bishow & Shah, Subhash & Timala, Rabindra. (2022). Pericardial cyst in a one-year-old boy with ventricular septal defect and patent ductus arteriosus. The Egyptian Heart Journal. 74. 10.1186/s43044-022-00278-6.

• Amatya, Manim & Pant, Anil. (2022). Clinical and histopathological study of renal biopsy in Nepalese children: A single center experience. PloS one. 17. e0276172. 10.1371/journal.pone.0276172.

• Khatiwada, Abhikanta & Jha, Anamika & Shrivastav, Shreya & Verma, Suman & C, Sharada. (2024). Large ovarian mature teratoma with gliomatosis peritonei in a young female: A case report. Radiology case reports. 19. 3970-3974. 10.1016/j.radcr.2024.06.018.

• Sharma, Nisha & Tiwari, Sansar & Gaire, Prabin & Manandhar, Usha & Bohara, Sujan & Nepal, Gaurav. (2023). An institutional experience of hydatidosis and cysticercosis in Nepal: a retrospective chart review. Annals of Medicine & Surgery. Publish Ahead of Print. 10.1097/MS9.0000000000000840.

• Mahat, Smritee & Manandhar, Usha & Rokaya, Nabin & Alam, Mohammad. (2023). Case Report: Neglected case of duodenal strongyloidiasis in an immunocompromised patient. F1000Research. 12. 307. 10.12688/f1000research.125447.1.

• Joshi, Padam Raj & Pandey, Sagar & Manandhar, Usha & G C, Saroj & Sedain, Gopal. (2022). Cerebral astroblastoma radiologically mimicking pilocytic astrocytoma: A case report. Clinical Case Reports. 10. 10.1002/ccr3.5781.

• Chalise S, Jha A, Neupane PR. Glomangiomyoma of Uncertain Malignant Potential in the Urinary Bladder: A Case Report. JNMA J Nepal Med Assoc. 2021 Jul 30;59(239):719-722. doi: 10.31729/jnma.5388. PMID: 34508517.

• Sherpa P, Jha A, Koirala S, Ghimire R. Polypoidal lesions of the gastrointestinal tract. May 2020 Journal of Pathology of Nepal 10(1):1625-162 DOI: 10.3126/jpn.v10i1.27743

• Amatya M, Pant AD, Sayami G, Banstola S.  Primary Cutaneous Diffuse Large B-Cell Lymphoma involving the Peripheral Blood and Prostate:  A Case Report.  Saudi Journal of Pathology and Microbiology 2021. 6(2) : 80-85

• Shrestha AL, Maharjan S, Pant AD, Nepali PB.  A Critically Ill Child with Gangrenous Appendicitis Masquerading as Hollow Viscous Perforation.  Case Reports in Critical Care 2020; 1-4

• Bhandari, A., Pant, A., Shrestha, A., &Thapa, J. (2019). Megakaryocytic alterations in bone marrow aspiration smears in thrombocytopenia. Journal of Pathology of Nepal, 9(2), 1523-1529.

• Shrestha P, Pokharel N, Pant AD. (2019). Bacteriology of blood stream infections in diabetic and non diabetic patients under the course of hemodialysis. J Microbiol Exp. 2019;7(1):41

• Melioidosis: misdiagnosed in Nepal. Nehashrestha, MAdhikari,V Pant, AnjanShrestha, BMC Infect Dis. 2019; 19: 176.

• A Rare and misdiagnosed entity PAROXYSMAL NOCTURNAL HEMOGLOBINURIA. A CASE REPORT. Karki S, Shrestha A. Cureus 2021 May 8;13(5):e14902. Epub 2021 May 8..

• Tuberculosis AND Evans syndrome. A case report. Karki S, Shrestha A. Clin Case Rep 2021 May 6;9(5):e04113. Epub 2021 May 6

• Hemochromatosis in B Thalassaemia patient with H63D homozygous mutation. A case report. Karki S, Shrestha A. Clin Case Rep 2020 Dec 12;8(12):2341-2345. Epub 2020 Jul 12.             

• Spectrum of Haematological malignancies managed at tertiary centre: A one-year retrospective review. Karki S, Shrestha A.  JSSN 2018; 21 (1) JSSN 2018; 21 (1)

• Granular  Cell  Tumor  of  Breast:  Rare  Tumor  Masquerading  as  Malignancy SuzitaHirachan, Yogendra P Singh, AnamikaJha, Usha Manandhar JIOM Nepal. 2020 Apr;42(1):62-64.

• A Rare Case of Primary Renal Lymphoma: Case report.  SmriteeMahat, UshaManandhar, Maya Bhatta, Sonafi Shrestha, Amit Sharma, Prabin Gaire, Gita Sayami

• Sharma N, Pant Anil, Manandhar Usha. Spectrum of hemoglobinopathies in a tertiary care centre. JPN. 2020; 10(1):1645-49

• Tumour angiogenesis and c-Met pathway activation – implications in breast cancer. Mitra S, Bal A, Kashyap D, Kumar S, Shrivastav S, Das A, Singh G.. (2020) APMIS. 2;128(4):316-325. doi: 10.1111/ 

• Giant cell glioblastoma in 6‐year‐old kid: Report of an unusual case. Shrestha, S., Homagain, S., Raut, A., Sedhain, G., Bhatta, S., & Shrivastav, S. (2020). Clinical Case Reports. doi: 10.1002/ccr3.3102 

• Paragonimiasis: A missed diagnosis from Nepal. Shrivastav, S., Jha A. (2020). Respiratory Medicine Case reports. Available online 19 November 2020. 

• The Bethesda System for Reporting Thyroid Cytopathology: Validating at Tribhuvan University Teaching Hospital. Acharya, K., Shrivastav, S., Triipathi, P., Gyawali, B., Kharel, B., Baskota, D., & Sinha, P. (2021). International Archives Of Otorhinolaryngology. doi: 10.1055/s-0041-1730298
• Karna A, Sharma N. Adenoid Basal Carcinoma of Cervix: A Rare Case Report. Nepalese Medical Journal. 2020; 3(2):392-94.

• Shrestha P, Rawal S, Sharma N. Relaparotomy in residual ovarian syndrome: an appraisal. Journal of Chitwan Medical College. 2020; 10(4):43-46.

• Gaire D, Maharjan D, Sharma N. Mixed adenoneuroendocrine carcinoma of proximal stomach; a rare but sinister pathology. JPN. 2020; 10(2):1772-75.

• Sharma N, Karn Alina, Jha Abhimanyu. Low Grade Appendiceal Mucinous Neoplasm: A Report of Three Cases. JIOM. 2020; 42(1):65-67.

• Adrenal schwannoma: A case report of an unusual incidentaloma. Sujan Timilsina  , Surya Prakash Joshi  , Sujan Sharma , Sanjeev Kharel  , Shovana Karki  , Sansar Babu Tiwari  , Durga Pandit , Purushottam Parajuli. ACPN 2023
• Epithelioid Gastrointestinal Stromal Tumor of Duodenum Mimicking Adenocarcinoma: A Case Report Sansar Babu Tiwari, Shovana Karki  ACPN 2023
• Inherited bone marrow failure syndromes: Shovana Karki  ACPN2023
• Unusual occurrence of tuberculosis in mature cystic teratoma. Sanjib Pariyar, Shovana Karki  ACPN 2023
• Histopathological Findings of Pancreaticoduodenectomy Specimens in a Tertiary Care Hospital in Nepal. Shovana Karki , Sonafi Shrestha , Sansar B Tiwari , Paleswan Joshi Lakhey ACPN 2023

INTERDEPARTMENTAL RESEARCH:

1. C10 and PDLA1 expression in Invasive Breast Cancer.  Shrivastav, Shreya & Sharma, Nisha & Hirachan, Suzita.  Campus Grant 2024

2.  Prevalence of Sjogren’s Syndrome in patients with Dry Eye in a Tertiary Hospital in Kathmandu.  Chaudhary, Meenu & Sitaula, Sanjeela & Jha, Saket & Pant, Anil Dev.  NHRC 2022